Compulsive Scratching: Beyond Willpower—Brain Science, Ketamine Therapy & New Paths to Relief

Please note that throughout this blog, we may refer to ketamine, esketamine, and Spravato relatively interchangeably. This is due to the inherent similarities in chemical makeup between ketamine and esketamine, and their similar effects on mental health conditions. In the event that this creates confusion, don't hesitate to reach out to Lumin Health staff to ask any questions about treatment at hello@lumin.health or by scheduling a free consultation.

Understanding the Link Between Compulsive Scratching and Mental Health

Compulsive scratching, clinically known as dermatillomania or excoriation disorder, is rarely just a skin-deep issue. It is often a physical manifestation of underlying emotional distress, such as anxiety, OCD, or depression, where the brain becomes locked in a repetitive cycle as a way to self-soothe or regulate overwhelming feelings.

If you find yourself unable to stop scratching, it's not a failure of willpower. It's a sign that your brain may be stuck in a rigid pattern. For many, this behavior is a Body-Focused Repetitive Behavior (BFRB), a category of conditions where an individual repeatedly touches their body in a way that results in physical damage. This isn't a "bad habit"—it's a complex neuropsychiatric symptom that deserves compassionate, expert care.

Why "Just Stopping" Isn't the Answer: The Neurology of Being Stuck

The advice to "just stop" scratching is often as unhelpful as telling someone with depression to "just cheer up." These compulsive behaviors are deeply rooted in the brain's circuitry. Often, they are linked to overactivity in a brain system called the Default Mode Network (DMN). The DMN is responsible for self-referential thought, or "mind-wandering," and when it's too rigid, it can lead to cycles of rumination, anxiety, and the compulsive behaviors used to cope with them.

Your brain isn't broken—it may be stuck. The repetitive act of scratching provides a temporary release from internal tension, reinforcing the neural pathway and making the cycle harder to break over time. Standard treatments like SSRIs or traditional talk therapy can be helpful, but when they don't provide sufficient relief, it suggests the underlying neural patterns remain too rigid to change.

Dr. Ben Yudkoff, Chief Medical Officer at Lumin Health, notes, "We often see patients who feel immense shame about behaviors like compulsive scratching. Our first job is to remove that shame and understand the behavior not as a personal failing, but as a distress signal from the brain. It's telling us that its usual coping mechanisms are exhausted."

A Path Forward When You Feel Stuck: Neuroplasticity

The key to breaking these cycles lies in neuroplasticity—the brain's innate ability to form new connections and pathways. The goal of advanced psychiatric treatment is not just to manage symptoms, but to create a biological window where the brain is more receptive to change, allowing it to "unlearn" these stuck patterns.

This is where evidence-informed, medically supervised treatments can be a powerful option. A significant body of research explores how certain therapies can rapidly promote the growth of new neural connections. A 2021 study published in the American Journal of Psychiatry highlighted the potential for treatments that target the glutamate system to rapidly reduce symptoms of anhedonia and depression, which often co-occur with BFRBs. This research underscores the shift towards understanding and treating the biological roots of these conditions.

For individuals with treatment-resistant symptoms, a potential path forward involves medically-supervised ketamine therapy. This approach aims to directly foster neuroplasticity, creating an opportunity to build healthier coping mechanisms with the help of concurrent psychotherapy.

How Advanced Treatments May Help Break the Cycle

At clinics with academically-affiliated leadership like Lumin Health, the focus is on precise, targeted interventions. Options like ketamine therapy and Spravato work differently than traditional antidepressants by modulating a neurotransmitter called glutamate. This can lead to a rapid increase in neuroplasticity.

It’s critical to understand the distinction between these options:

The goal of using ketamine for depression and its related compulsive symptoms is not to "fix" the brain, but to make it more flexible and capable of change. This biological shift is then solidified and given direction through behavioral support and psychotherapy.

Frequently Asked Questions

Is compulsive scratching the same as self-harm?

While both can result in physical injury, the intent is different. Self-harm is often a direct attempt to cope with overwhelming emotional pain through physical pain. Compulsive scratching is typically a more unconscious, repetitive grooming behavior aimed at soothing anxiety or addressing perceived skin imperfections, though it exists on a spectrum and can overlap.

How exactly does ketamine for depression help with a physical behavior?

By quieting the overactive Default Mode Network and promoting neuroplasticity, a ketamine treatment may reduce the underlying anxiety and rumination that trigger the compulsive behavior. It creates a temporary state where the brain is less "stuck," making it more possible to engage in psychotherapy and build new, healthier behavioral responses.

Is Spravato better than other forms of ketamine therapy?

One is not inherently "better" than the other; they are different tools for different clinical situations. Spravato has the distinction of being FDA-approved for specific depressive disorders, which is a crucial factor for many patients and providers. The choice between IV ketamine therapy and the nasal spray esketamine is a clinical decision made with a psychiatrist after a thorough evaluation.

A Note For Those Seeking Care Outside of Massachusetts

Lumin Health is a psychiatrist-led organization located in Boston, MA, dedicated to providing personalized and attentive care for our local community. While we cannot provide treatment outside of our physical location, we believe in sharing accurate, evidence-based information to help empower individuals everywhere. We hope this guide serves as a valuable resource in your search for effective care, wherever you may be.

We Would Be Grateful to Walk With You

Feeling trapped by a behavior you can't control is isolating. At Lumin Health, we see the person, not just the symptom. Our approach is a partnership, grounded in clinical excellence and deep empathy. If you are struggling and traditional treatments haven't provided the relief you deserve, it may be time to explore a different path. We would be grateful to walk with you towards relief.