Ketamine Therapy and Spravato (Esketamine) Treatment Services at Lumin Health

Spravato is the brand name for esketamine — the isolated S-ketamine molecule — delivered as an FDA-approved nasal spray for treatment-resistant depression. Generic ketamine is the racemic form (a 50/50 mix of R- and S-ketamine) used off-label. They share the same core mechanism in the brain; the practical differences are the molecule, delivery route, FDA status, and insurance coverage. At Lumin Health we offer both Spravato and intramuscular (IM) ketamine. For a full breakdown, read our guide to Spravato vs. ketamine — what's the difference.

Spravato (esketamine) is FDA-approved and covered by most major commercial health insurances, including BlueCross and Mass General Brigham. IV Ketamine is often considered off-label and requires out-of-pocket payment, though superbills can be provided for potential out-of-network reimbursement. We verify all benefits before starting.

Patients typically sit in a comfortable, private room for about two hours. You may experience a floating sensation, deep relaxation, or mild dissociative effects. A medical provider monitors your vitals and comfort the entire time. You must have a driver take you home afterward.

These treatments are primarily for individuals who have tried at least two different antidepressant medications without adequate relief (Treatment-Resistant Depression), or those suffering from severe Anxiety, PTSD, or OCD. A full psychiatric evaluation by our team will determine if this path is safe and right for you.