Ketamine Therapy and Spravato (Esketamine) Treatment for Depression Relief

Ketamine was developed in the 1960s as an anesthetic to help people sleep before surgery. While high doses induce sleep, lower doses actually stimulate the brain. This unique effect led researchers in the late 1990s and early 2000s to explore low-dose ketamine as a novel antidepressant, given its potential to promote brain cell activity and change.

At low doses, ketamine stimulates brain cells much like exercise stimulates muscles. This leads to the release of a growth hormone called Brain-Derived Neurotrophic Factor (BDNF). BDNF encourages the growth of new connections between brain cells, known as synapses, which may be reduced in cases of treatment-resistant depression. By promoting synapse growth, ketamine and Spravato (esketamine) can help reverse some brain changes associated with depression.

These medications also affect the Default Mode Network (DMN) in the brain – a circuit involved in processing the world around us, storing personal memories, reflecting on emotions, and social interactions. In depression and other psychiatric conditions, the DMN may function differently. After ketamine or Spravato (esketamine) administration, the DMN is temporarily disrupted, potentially altering thought processes. As the medication clears from the system over several hours, research suggests the DMN returns to healthier functioning.

Additionally, ketamine interacts with opioid receptors in the brain – the same receptors that respond to endorphins and create a "runner's high" – which can elevate mood. The medicine also alters the function of a type of cell in the brain called an "astrocyte," changing the way your brain measures how feasible a task appears to be. The medicine helps the brain see possibility where it once only interpreted futility.

Beyond biological effects, ketamine and Spravato (esketamine) can open doors to new ways of thinking and perceiving. During treatment, you may experience a sense of warmth and relaxation, with a heightened awareness of the present moment. Many people describe feeling a gentle detachment from everyday concerns, allowing for profound insights and a fresh perspective on life.

Some individuals report seeing calming patterns or colors, and sounds may become more vivid and soothing. This serene state can help you reconnect with yourself and explore positive emotions and thoughts. The experience typically lasts between 30 to 120 minutes, providing a peaceful interlude that can contribute to your healing journey.

We are dedicated to making your treatment as comfortable and uplifting as possible. Our tranquil setting is designed to support your well-being. We recommend wearing cozy clothing and bringing headphones to enjoy calming music during your session.

Ketamine consists of two mirror-image molecules, similar to how your left and right hands are mirror images. Spravato (esketamine) is the left-sided oriented molecule. Differences between ketamine and esketamine are as below.

Ketamine consists of two mirror-image molecules, similar to how your left and right hands are mirror images. Spravato (esketamine) is one of these molecules. Due to differences in absorption:

Due to regulatory differences, ketamine and Spravato (esketamine) are used for various conditions: