Dr. Ben Yudkoff, Co-Founder and Chief Medical Officer at Lumin Health, hosted a Reddit AMA on r/TherapeuticKetamine community on March 6th, 2026\. The below blog post is a recap of one of the questions presented on that AMA, syndicated to the Lumin Health blog in the event that it answers any questions about ketamine therapy, Spravato treatment, or general concerns you may have about treatment.
[https://www.reddit.com/r/TherapeuticKetamine/comments/1rj2blv/ama\_im\_dr\_ben\_yudkoff\_psychiatrist\_cofounder/](https://www.reddit.com/r/TherapeuticKetamine/comments/1rj2blv/ama_im_dr_ben_yudkoff_psychiatrist_cofounder/)
Don’t hesitate to get in touch with us if you’re interested in learning more about ketamine for depression at Lumin Health. Thank you once again to the moderators and community members for facilitating such an engaging discussion.
Turkaturk asks:
I am a bigger guys 250 lbs and recently switch to dissolvable tabs twice a week at a dose of 200mgs. This dose feels way weaker than Spravato that I was on. I have also done IV Ketamine and think that was the most beneficial but can’t keep doing it due to cost.
Would it be reasonable to ask my psychiatrist to increase the dose and go to three times a week instead of two times a week.
I have crohn’s and been in a flair since September of 2025\. Since I am immune compromised I have been in the hospital now 5 times with different infections so my quality of life hasn’t been great and I have a family with three kids and a full time job that I am trying to give my all to them and it is draining and deeply depressing.
Answer from Dr. Ben Yudkoff, Co-Founder and Chief Medical Officer of Lumin Health:
Captain Turk\! You’re touching an interesting nuance of ketamine. Ketamine is composed of two mirror image molecules – r-ketamine and s-ketamine. The r-ketamine is poorly absorbed through mucosa (the pink skin that lines the insides of our noses, mouths, etc.) while the s-ketamine (aka esketamine) is more readily absorbed. One other foundational bit of info: any ketamine (r-ketamine or s-ketamine) that is swallowed is mostly rendered inactive (i.e., metabolized). So in that tab you take, half of the dose (the r-ketamine component)
The dissolvable tabs are equal parts r-ketamine and s-ketamine, meaning that half of the dose is largely unusable. What portion of the s-ketamine ends up being absorbed has a lot to do with surface area of contact and how much is swallowed/spat out.
I can’t really give advice on what’s reasonable to ask regarding the dosage and the frequency without knowing a little more, but for frame of reference, 200 mg for a bigger bodied person may be on the low-moderate side for a bigger bodied person. It’s also totally reasonable to ask for some additional support when so much is up in the air (like your health). Feel better, Turk. I hope the info provided helps you and your provider sort next steps.
