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Right arrow | Lumin Health | 5.0 star insurance-covered ketamine therapy and esketamine (Spravato) treatment for depression, anxiety and PTSD in Boston MA and Greater Boston Area, Massachusetts

Lumin Health's comforting environment for ketamine therapy

Relax in our serene private treatment suites, featuring blankets, pillows, eye masks, and other amenities. Our calming setting, enhanced by refreshments and occasional visits from friendly puppies, boosts the effectiveness of your treatments and enriches your experience, allowing you to focus on healing in comfort.

The view of an entire room at Lumin Health, designed for comfort and safety in administering ketamine therapy.

Some plants, natural light, and detailed fixtures as part of a ketamine therapy treatment room at Lumin Health.

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Natural light, plant life, and comfort are front and center in Lumin Health's ketamine treatment rooms.

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Image of some of the attentions to detail to make Lumin Health's clinics in the Boston area for ketamine therapy and Spravato treatment more warm and inviting

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Image of treatment rooms at Lumin Health in Boston for ketamine therapy and Spravato treatment more warm and inviting

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Plus sign | Lumin Health | 5.0 star insurance-covered ketamine therapy and esketamine (Spravato) treatment for depression, anxiety and PTSD in Boston MA and Greater Boston Area, Massachusetts

Minus sign | Lumin Health | 5.0 star insurance-covered ketamine therapy and esketamine (Spravato) treatment for depression, anxiety and PTSD in Boston MA and Greater Boston Area, Massachusetts

What is ketamine therapy for depression and how can it help treat mental health conditions?

Ketamine therapy is an innovative treatment that uses low doses of the anesthetic ketamine to rapidly alleviate symptoms of severe depression and anxiety. It’s often considered when conventional treatments (like standard antidepressant medications or talk therapy) haven’t provided relief. Unlike traditional antidepressants which can take weeks to work, ketamine can improve mood within hours or days by acting on different brain pathways (primarily the glutamate system). This therapy has shown success in treating treatment-resistant depression – cases where multiple antidepressants haven’t helped – and has even reduced suicidal thoughts in some patients. Ketamine has also delivered positive results for people with hard-to-treat anxiety disorders, offering new hope when standard anti-anxiety treatments fall short. All treatments are provided under careful medical supervision to ensure safety while helping individuals reclaim a happier, more stable life.

What is the difference between ketamine treatment and Spravato (esketamine)?

Esketamine (also called Spravato) is a form of ketamine that has been developed as an FDA-approved nasal spray for depression. It consists of one of the two mirror-image molecules in ketamine and is approved specifically for adults with treatment-resistant depression (and those with major depression and acute suicidal ideation). Spravato is administered in a clinic under medical supervision as a nasal spray, and because of its FDA approval it’s covered by most insurance plans for those who meet criteria. Ketamine, on the other hand, refers to the original compound (containing both mirror-image components) and is typically given off-label via intravenous (IV) infusions or intramuscular (IM) injections for mood disorders. Both ketamine and esketamine produce similar antidepressant effects on the brain, but standard ketamine use for depression is off-label (not formally FDA-approved for this purpose), so insurance usually does not cover IV/IM ketamine treatments. At Lumin Health, our experts offer both Spravato and ketamine therapy – we’ll help determine which option is best for you based on your condition, treatment history, and insurance coverage.

Is ketamine therapy safe, and what are the side effects?

Yes, ketamine therapy is considered safe for depression and anxiety for lots of people when it’s administered by trained medical professionals in a proper clinical setting. At Lumin Health, treatments are overseen by our board-certified team (led by a Harvard-trained psychiatrist) following strict safety protocols and FDA guidelines. We thoroughly screen each patient to ensure ketamine is appropriate for them, and we monitor you closely during every session. Like any medical intervention, ketamine can cause side effects, but these are generally temporary and manageable. Common side effects experienced during or shortly after a session include dissociation (feeling “floaty” or detached, sometimes described as a dreamlike state), drowsiness, mild hallucinations or altered perception, dizziness, blurred vision, increased blood pressure or heart rate, and occasionally nausea or headache. These effects wear off as the drug exits your system, typically within minutes to a couple of hours after treatment. In fact, most people feel back to normal by later the same day, aside from possible mild fatigue. It’s worth noting that the doses of ketamine used for therapy are much lower than those used in anesthesia or taken recreationally, so we do not aim to put you “under” or make you hallucinate wildly. Our team carefully calibrates the dose to minimize any psychedelic effects – patients do not lose touch with reality or control during treatment. Overall, ketamine has a strong safety record in medical use, and our clinic’s monitoring ensures that if you do experience side effects like a rise in blood pressure or nausea, we can address them immediately. Your well-being is our top priority.

Does insurance cover ketamine therapy or Spravato, and what does it cost?

Insurance Coverage: Coverage depends on the type of treatment. Esketamine (Spravato) – the FDA-approved nasal spray for depression – is covered by Medicare and most major private insurance plans for patients who meet the criteria (generally, those with treatment-resistant depression who have tried other antidepressants). If you qualify for Spravato, your insurer will typically pay for the medication and treatment sessions, leaving you with only a co-pay or deductible similar to a regular specialist visit. Lumin Health works with a wide range of insurers (including Aetna, Blue Cross Blue Shield, Cigna, United Healthcare, Medicare, and others), and about 95% of our patients have Spravato treatment covered by their insurance, making it very accessible and affordable. We handle the insurance authorization process for Spravato and will let you know upfront if you’re covered.
Out-of-Pocket Costs: Ketamine infusion or injection therapy (the off-label treatment) is typically not covered by insurance for depression or anxiety. This means patients opting for IV or IM ketamine will usually pay out-of-pocket. At Lumin Health, we strive to keep ketamine therapy affordable and transparent. We charge about $500 per session for intramuscular ketamine treatments, and a typical full treatment package (6–10 sessions over several weeks) ranges from roughly $3,000 to $5,000 in total. This per-session cost is often significantly lower than many hospital-based IV ketamine infusions (which can run $600–$1,000 or more each). We also offer flexible payment plans and will work with you to minimize financial barriers – our team can discuss financing options during your consultation. In summary, insurance will pay for Spravato in most cases (making that option low-cost for you), whereas ketamine IV/IM therapy is self-pay but priced with affordability in mind. We’re committed to helping you get the treatment you need, and we’ll guide you through the costs and insurance details so there are no surprises.

How do I know if I’m a good candidate for ketamine therapy, and how can I start treatment?

Ketamine therapy is generally recommended for individuals with serious depression or related conditions that haven’t responded well to standard treatments. If you have tried traditional antidepressants and talk therapy without sufficient improvement, you may be a good candidate to consider ketamine or esketamine. The best way to know for sure is to have a professional evaluation. At Lumin Health, our experienced medical team will conduct a thorough assessment of your medical history, current symptoms, and past treatment trials to determine if ketamine or Spravato is appropriate and safe for you. We take into account factors like your diagnosis, how many treatments you’ve tried, and any health issues that might affect ketamine’s treatment. If you’re deemed a good candidate and you decide to proceed, starting treatment is straightforward – you can book a free consultation with us (online or by phone at 617-863-8810) to discuss your case and ask any questions. From the initial consultation to your first session, the process is usually quick. In fact, most patients can begin treatment within a few weeks after the evaluation (and we do our best to accommodate urgent cases faster). Our staff will guide you through every step – verifying your insurance coverage for Spravato (esketamine) if applicable or discussing payment options for ketamine, scheduling your appointments, and coordinating care with your existing providers if needed. This personalized intake process ensures that you feel informed and supported from day one so you can start your ketamine therapy journey with confidence and hope for relief.

Lumin Health of Greater Boston provides evidence-based Spravato (esketamine) therapy and ketamine therapy to treat a host of different psychiatric problems, like depression, anxiety, OCD, and PTSD.

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Locations and Hours

Newton Center
10 Langley Rd., Suite 200
Newton MA 02459 Cambridge (Harvard Square)
50 Church St., 3rd floor
Cambridge MA 02138 Woburn
300 TradeCenter Drive, Suite 3460
Woburn, MA 01801 Brookline
1101 Beacon Street, Suite 6E
Brookline, MA 02446

Monday - Friday, 8am - 6pm

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Lumin Health's comforting environment for ketamine therapy

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Meet Dr. Ben Yudkoff,
Lumin Health’s Chief Medical Officer and expert in ketamine therapy