Can You Safely Continue Spravato Online? What to Know About At-Home Ketamine Options

Please note that throughout this blog, we may refer to ketamine, esketamine, and Spravato relatively interchangeably. This is due to the inherent similarities in chemical makeup between ketamine and esketamine, and their similar effects on mental health conditions. In the event that this creates confusion, don't hesitate to reach out to Lumin Health staff to ask any questions about treatment at hello@lumin.health or by scheduling a free consultation.

Dr. Ben Yudkoff, Co-Founder and Chief Medical Officer at Lumin Health, hosted a Reddit AMA on the Spravato community on November 21, 2025. The below blog post is a recap of one of the questions presented on that AMA, syndicated to the Lumin Health blog in the event that it answers any questions about ketamine therapy, Spravato treatment, or general concerns you may have about treatment. 

https://www.reddit.com/r/Spravato/comments/1p2ar6v/ama_im_dr_ben_yudkoff_psychiatrist_cofounder/ 

Don’t hesitate to get in touch with us if you’re interested in learning more about ketamine for depression at Lumin Health. Thank you once again to the moderators and community members for facilitating such an engaging discussion. 

BettyJustHitTheWall asks: 

Hi, Dr. Ben. TYSM for doing this AMA. I did my initial two-month protocol, then returned for four sessions after a dip in mood. I’ve since moved to a different state and am having trouble finding a clinic that provides Spravato. Do you think any of the online options (e.g., Innerwell) are worth investigating?

Answer: 

Betty, that's a great question. Online options may be worth investigating so long as the risks are understood. With online treatment a person is physically unaccompanied and so if a person has a bad side effect there's no ability of in-person clinical personnel to respond and help out. Most online sites provide lonzenges (or what we call "troches") which have a much less predictable absorbability ,and so inherently introduce a much higher variability in the dose somebody is getting.

Having said that, these online sources offer some level of accessibility. They are more expensive than standard insurance covered Spravato, but the expense is something that a lot of people have the ability to build into a budget. I can't speak to whether one particular online site is more reputable than another, but I do know that a lot of people are finding that as they're trying to compromise between what I'd argue are the higher quality, in-clinic medicalized experiences (with the ability of personnel to be responsive in case there's a side effect and people onsite to walk a person through difficult moments) and the more accessible online platforms, thinking about how you tolerated your treatments, any risk that others may take the medication from you, and what you want, presently, are all important factors. At the end of the day, if you found the treatments helpful, finding a path to safely re-engaging treatment is of the upmost importance.