Does Ketamine Treat Stress-Related Anhedonia?

Please note that throughout this blog, we may refer to ketamine, esketamine, and Spravato relatively interchangeably. This is due to the inherent similarities in chemical makeup between ketamine and esketamine, and their similar effects on mental health conditions. In the event that this creates confusion, don't hesitate to reach out to Lumin Health staff to ask any questions about treatment at hello@lumin.health or by scheduling a free consultation.

Dr. Ben Yudkoff, Co-Founder and Chief Medical Officer at Lumin Health, hosted a Reddit AMA on r/TherapeuticKetamine community on March 6th, 2026\. The below blog post is a recap of one of the questions presented on that AMA, syndicated to the Lumin Health blog in the event that it answers any questions about ketamine therapy, Spravato treatment, or general concerns you may have about treatment.

[https://www.reddit.com/r/TherapeuticKetamine/comments/1rj2blv/ama\_im\_dr\_ben\_yudkoff\_psychiatrist\_cofounder/](https://www.reddit.com/r/TherapeuticKetamine/comments/1rj2blv/ama_im_dr_ben_yudkoff_psychiatrist_cofounder/)

Don’t hesitate to get in touch with us if you’re interested in learning more about ketamine for depression at Lumin Health. Thank you once again to the moderators and community members for facilitating such an engaging discussion.


Disastrous\_Iron\_8366 asks:

Did help with anhedonia form stress?

Answer from Dr. Ben Yudkoff, Co-Founder and Chief Medical Officer of Lumin Health:

DI\! Anhedonia associated with stress has not been systematically studied, but anhedonia as a unique neuropsychiatric symptom has been (see https://pubmed.ncbi.nlm.nih.gov/35292831/). Anhedonia is often parsed from the broader symptom cluster of depression and regarded separately. While I can’t say for certain, translating some of the studies into real world experience lends some good suggestions that ketamine can treat an independently anhedonia.

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